Medical R&D miracle

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SAN DIEGO -- The California biotechnology industry recently gathered for its annual CALBIO conference. Participants were excited at the prospect of developing new medical miracles. But the potential of government interference hung over the proceedings like dark clouds on the horizon.

Nearly $50 billion was spent last year in pharmaceutical and biotech research and development. The big drugmakers devoted $38.8 billion to finding new cures. A bevy of smaller biotech companies spent another $10.5 billion.

The United States dominates the biopharmaceutical industry worldwide. America's advantage is not that its citizens are smarter, better educated or nicer. Rather, America is freer.

Despite manifold regulation by states as well as the federal government, it is still easier to conduct research, create products and sell medicines in the United States than overseas. In contrast, Europe faces a full-scale scientific brain drain in many industries due to its stultifying economic environment.

American dominance results in increased economic activity, particularly sales and employment.

Biopharmaceutical leaders are financial leaders. Pfizer ranks No. 24 on the Fortune 500. Johnson & Johnson comes in at 30 and Merck at 84. There are a half dozen more in the top 500 companies and another 11 in the next 500.

Biotech concerns typically don't rate a Fortune 500 mention.

Nevertheless, the nearly 1,500 firms are enormously important, offering diverse entrepreneurial possibilities.

Revenues for the top three drugmakers alone run $123 billion. Their total employment is 288,000. Indeed, Pfizer and Johnson & Johnson have larger work forces than Exxon Mobil, No. two on the Fortune 500 list.

A new study for the Milken Institute figures that the biopharmaceutical industry collectively employed 406,700 people in 2003. Moreover, "Each job in the industry creates another 5.7 jobs elsewhere in the economy, substantially above the average for all industries."