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Francis had won his last three starts and was 4-0 in his previous five. Before Markakis connected, Francis had yielded only one home run in 55 innings of interleague play — to Baltimore’s Miguel Tejada on June 19, 2005.

“Bad pitch selection, more of a mental error than a physical error,” Francis said. “That’s what’s frustrating about losing a game like that. That’s the difference, and that’s a stupid mistake.”

Yorvit Torrealba homered for the Rockies, who had won four of five and 11 of 15.

The Orioles took a 2-0 lead in the first. After Jay Payton walked and Markakis singled, Kevin Millar and Aubrey Huff delivered two-out RBI singles.

Held to three hits over the first four innings, the Rockies got a run in the fifth and were left wanting more. After Torrealba homered with two outs, Colorado put runners on second and third before Trachsel retired Matt Holliday on a fly to center.

Baltimore went up 4-1 in the bottom half. Payton reached on a fielder’s choice and Markakis drove a 2-1 pitch over the right-field scoreboard.

Helton hit a leadoff double in the sixth and scored on Trachsel’s balk.