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“Defense can cast blame, if that’s how they choose to go. They can say that Lowe committed the bad acts and Thompson didn’t know what was happening,” said Denver lawyer Scott Robinson, who has followed the case.

Prosecutors may be forced to build their case around testimony from the other children. “We won’t really know until the prosecution makes its opening statements, which will probably be Thursday,” Mr. Robinson said.

Jury selection began Monday in the trial, which is expected to last about a month.