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He ignored a shouted question about the lack of Republican support.

White House press secretary Robert Gibbs was informed of the House passage, and the fact that not one Republican voted for the bill, as he was walking off the dais in the Brady press briefing room.

Responding to the lack of Republican support, Mr. Gibbs put up his hand as if to say, “What can you do?” and said: “3.5 million jobs that we look forward to saving or creating.”

“Have a good weekend,” he said, walking out of the room.

Earlier in the televised briefing, Mr. Gibbs had said it was “silly” to talk of bipartisanship being dead.

“When the dust finally settles you’ll see an economic recovery plan that moves forward because Democrats and Republicans worked together to get it to the president’s desk,” he said.

The Senate vote will require a 60-vote supermajority to overcome Republican objections to the bill’s impact on the budget. With ailing Sen. Edward M. Kennedy, Massachusetts Democrat, not expected to vote on the bill, Senate Democrats will need all three Republicans and every member of the Democratic caucus to pass the bill.

House and Senate Democrats argued Wednesday during negotiations to reconcile the Senate’s $838 billion bill and the $819 billion House-passed version. A tentative deal announced by Senate Majority Leader Harry Reid, Nevada Democrat, was called into doubt when House Democratic leaders did not show up for the conference committee meeting.

House Speaker Nancy Pelosi of California, particularly miffed that Mr. Reid cut $16 billion in federal funding for schools, initially withheld public approval of the deal.

But Democrats since have presented a united front, warning that failure to enact the measure would have dire consequence to a domestic economy already in trouble.

“I think this is a key part of what’s gong to be a multipart strategy to contain this decline,” said Larry Summers, who heads the White House-based economics council, on NBC’s “Today” show Friday.

He added that while the package shouldn’t be considered a “silver bullet” to cure the country’s economic woes, “We don’t have a viable alternative.”

Jon Ward contributed to this article.