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Williams‘ older sister Venus, who is seeded No. 3, could face an intriguing matchup in the third round against No. 32-seeded Tsvetana Pironkova of Bulgaria. Pironkova has won two of her previous three matches against Venus Williams, including a straight-set upset in the Wimbledon quarterfinals June 29.

That was the last match Williams played on tour; she sprained her left kneecap in early August, forcing her to withdraw from hard-court tournaments at Cincinnati and Montreal.

The U.S. Open begins Monday, and Williams will have gone more than two months without a match by the time she meets her first-round opponent, Roberta Vinci of Italy, who is 1-7 for her career at Flushing Meadows.