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“I can’t imagine him playing this week,” Gailey said. “We’ll have to see how long it lasts.”

In becoming the NFL’s final team to win this season, the Bills (1-8) also lost defensive lineman Spencer Johnson to a hamstring injury in the second half.

Spiller, the rookie first-round pick, was hurt after he was hit along the sideline and pushed out of bounds by Detroit’s Vinny Ciurciu after returning a punt 29 yards with 9 1/2 minutes left in the second quarter.

San Francisco 49ers left tackle Joe Staley is out indefinitely after breaking his left leg during a 23-20 overtime win against the St. Louis Rams.

The fourth-year starter was on crutches after the game. Staley apparently kept playing after an initial injury, but committed two penalties on San Francisco’s go-ahead drive late in the fourth quarter. His holding penalty wiped out Troy Smith’s 43-yard TD pass to Vernon Davis.

Cleveland’s Joshua Cribbs hurt his right foot in the second quarter in the team’s overtime loss to the New York Jets and did not return. Linebacker Scott Fujita, possibly the team’s defensive MVP, injured his left knee and sat out the second half. And, cornerback Sheldon Brown hurt his left shoulder tackling Braylon Edwards.

Dallas Cowboys cornerbacks Terence Newman and Michael Jenkins left the win against the New York Giants with injuries.

Newman was hurt with about six minutes remaining in the first quarter. He limped to the sideline, then walked to the locker room with a left ankle problem. Jenkins was sidelined by a neck injury sustained in the second quarter.