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“That actually wasn’t a terrible pitch,” Millwood said. “I threw it pretty close to where I wanted to. On that, you just tip your cap and move on.”

Reddick’s deep drive into the right-field seats made it 4-1 in the fifth.

Millwood, who has the most losses in the American League, gave up six runs and seven hits in five innings.

“We didn’t have many opportunities. I thought their pitcher was carrying a good fastball early,” Orioles manager Buck Showalter said. “You can see when a guy throws that many fastballs early. You can see when a guy throws that many fastballs early in a game, he has confidence in it.”

Boston closer Jonathan Papelbon pitched a one-hit ninth, striking out three, one night after allowing four runs in a non-save situation.

The Red Sox chased Millwood with two runs in the sixth. Ortiz’s RBI single made it 5-1. Adrian Beltre added an RBI double off reliever David Hernandez.

Baltimore took a 1-0 lead in the fourth on Ty Wigginton’s RBI double.

NOTES: The teams split the season series 9-9. … The Red Sox were swept at home by Tampa Bay in April and the White Sox earlier this month. … Lackey went over 200 innings for the fifth time in his career. … Showalter announced most of his rotation for this weekend in Toronto: RHP Chris Tillman will start Friday, Jeremy Guthrie on Saturday, but he was still undecided for Sunday. … Boston’s Ryan Kalish shattered his bat on a single to right and the end went flying about 10 rows back behind the Red Sox on-deck circle, where it was caught by a fan. … Baltimore’s Nick Markakis has 43 doubles this year; his fourth straight year with at least that many. He’s just the third player in major league history to accomplish that feat. Hall of Famers Joe Medwick (1935-39) and Tris Speaker (1920-23) are the others. … Boston 3B Adrian Beltre needs one RBI for his second career 100-RBI season. The other came with the Los Angeles Dodgers in 2004.