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“A lot will depend from our serves. I need to serve well because that’s something that he’s going to do, for sure,” Djokovic said of Tsonga, the man he beat to win the 2008 Australian Open title. “I think his game as well depends on that serve. If he starts missing first serves, then I can have some more chances in the rallies.”

On the other side of the draw, Nadal will have to defend his title against Murray and the British public, and he’ll have to do it with his injured left foot.

The 10-time Grand Slam champion hurt himself in the previous round, but a painkilling injection numbed his foot for the match against Fish on Court 1.

“My foot is not fine,” said Nadal, who didn’t appear to be hampered at all Wednesday. “But we are in quarterfinals of Wimbledon. Is an emergency, so I had to play.”

Nadal is 11-4 against Murray, including a victory in last year’s Wimbledon semifinals and in this year’s French Open semifinals.

“You get pushed more and more as the rounds go on,” said Murray, a three-time Grand Slam finalist who is trying to become the first Britain man to win the Wimbledon title since Fred Perry in 1936.

“I’m sure in the next round, I’m going to get pushed even harder, and I’m going to have to up my game again.”

That’s exactly what Tsonga did when he needed to do it most against Federer.

“I felt so good on the court,” Tsonga said. “I was just perfect today.”