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Ramirez hit two of the hardest balls off Liriano. He lined out to third in the first and sent a hard liner foul past third in the sixth.

Edwin Jackson (2-4) lost his fourth straight start despite allowing six hits in eight innings. Then with Arizona, Jackson no-hit Tampa Bay last June 26 despite walking eight.

It was the seventh no-hitter for the Twins-Washington Senators franchise and the first since Eric Milton’s against the Angels on Sept. 11, 1999. It was the first no-hitter in the major leagues since Philadelphia’s Roy Halladay’s against Cincinnati in last year’s NL division series.

The White Sox were no-hit for the 13th time, the first since they were beaten by Kansas City’s Bret Saberhagen on Aug. 26, 1991.

Liriano was acquired in 2003 in the famously lopsided trade that also brought Joe Nathan to Minnesota in exchange for A.J. Pierzynski.

He burst onto the scene in 2006, going 12-3 with a 2.16 ERA and dominating overmatched hitters with an untouchable slider. But the violent delivery caused him to develop arm problems toward the end of that season and had elbow-ligament replacement surgery that November.

His road back has been a long and difficult one. He missed all of 2007, then struggled to regain his form over the next two years, leading some to wonder if he ever would make it all the way back after going 5-13 with a 5.80 ERA in 2009.