The punch came just after the two fighters had hugged in the middle of the ring after a head butt by Ortiz clearly irritated Mayweather. As they separated, Mayweather shot out a right hand that put Ortiz on the canvas, and he was counted out as he struggled to get up.
It was a wild end to a fight that Mayweather was dominating until Ortiz seemed to intentionally head butt him in the corner. After referee Joe Cortez took away a point and separated them, the two met in the center of the ring to resume action.
It was the 42nd straight win for Mayweather as a pro.
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