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“It’s been a year of a few ups and downs, but a lot of players go through that,” Stosur said. “In the last few weeks, being on hard court, I feel a lot better and a lot more comfortable on this surface. It’s conditions that suits my game, so I’m glad to be back here.”

No American man hasn won the U.S. Open since Andy Roddick in 2003. There are four seeded U.S. men trying to halt that streak: No. 9 John Isner, No. 23 Mardy Fish, No. 27 Sam Querrey and Roddick, who is seeded 20th. Roddick won a hard-court tournament in Atlanta in July, but has since fallen to Djokovic in the second round of the Olympics, then to 38th-ranked Jeremy Chardy in the first round in Cincinnati.

James Blake and Ryan Harrison are among the unseeded Americans in the draw. Roddick could face del Potro in the fourth round, while Isner is in the same quarter of the draw as Ferrer.

Federer, who has a record 17 Grand Slam titles, opens against another American, Donald Young, who is 2-20 this year.

Djokovic’s first match is against 69th-ranked Paolo Lorenzi of Italy.

Serena Williams opens against another American, Coco Vandeweghe, the 2008 girls champion.