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Pistorius is an accomplished runner, with four Paralympic gold medals, but he waged a long fight to run in the Olympics against able-bodied opponents.

After dozens of hearings in front of hundreds of men and women in suits charged with the task of deciding whether the blades gave Pistorius an unfair advantage — then getting his country’s Olympic committee to accept his qualifying times and enter him into the games — Pistorius finally got his chance.

He shook hands with his opponents, crouched into the blocks, flashed that smile and then — in so many ways, it was just another race, with Pistorius among the fastest men in it.

“You’ve got to understand that Oscar is an exceptional athlete,” said Versfeld, the surgeon. “I mean, he is an amazingly talented person. I think the chances that there are going to be many other athletes with disabilities, amputations, I think the chances that they will be able to compete with able-bodied athletes is not high and I really think we are seeing a one-off type situation.”

Bursting out of the crouch from Lane 6, Pistorius got going slowly, but built up steam in the backstretch. He made up the lag and was easily among the top three when the runners turned into the backstretch. He passed Russia’s Maksim Dyldin and then, as all the top runners do in a 400 prelim, eased off the gas over the final few meters to save energy for the next one.

Though he knows his personal-best of 45.07 seconds isn’t fast enough to truly contend for a medal, Pistorius wants to be more than simply a set piece at these Olympics. His goal was to be a factor, to earn a spot in the semifinals, and he did that — something the defending champion in this event, LaShawn Merritt, did not.

“He’s fought to get here. He’s here. Great guy, friend of mine,” said Merritt, who pulled up lame with an injured hamstring halfway through his race and won’t get to face Pistorius on the track.

One man who might, Britain’s Nigel Levine, is among those who sounded less than thrilled about all the hype over Pistorius, who will also compete for South Africa in the 4x400-meter relay next week.

“Ask him,” Levine said when asked if Pistorius had an advantage. “I’ll keep my opinion to myself on that one. It has nothing to do with me.”

Advantage or no, getting to the semifinals was never a sure thing. Then again, there haven’t been many sure things for the “Blade Runner” on this Olympic road. And so, he appreciates every moment.

“It sometimes difficult to think the athletes and the friends and family of those who are here really understand what it’s about,” Pistorius said. “To be out here and to know you sacrificed ‘X’ amount to achieve this is just really mind-blowing.”

Associated Press reporter Ed Brown in Johannesburg contributed to this report.