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On Tuesday, they put two running backs, starter Donald Brown (high ankle sprain) and fourth-stringer Robert Hughes (knee), on season-ending injured reserve. Third-stringer Delone Carter has been hobbled by an ankle injury, too, so Indy re-signed veteran Mewelde Moore and rookie Deji Karim, who were both cut by the Colts earlier this season.

That’s not all.

Arians could not say Wednesday whether offensive linemen right tackle Winston Justice (biceps), left guard Joe Reitz (head) or center Samson Satele (ankle) would play Sunday, either. Justice and Satele did not finish last weekend’s game against Tennessee and did not practice Wednesday. Reitz missed his eighth start of the season last weekend, but was fine on Wednesday.

Facing an angry Houston squad, stinging from the 42-14 rout by the Patriots, with a makeshift offensive line certainly isn’t the ideal way to go into such a high-stakes game.

A victory would allow the Texans to take another step toward clinching the AFC’s top seed and would help reassert their image as a Super Bowl favorite.

For Indy, the game is just as important. It’s an opportunity for the Colts to show the football world they can go toe-to-toe with the league’s top teams, home or away, with or without injuries and despite the resume that they deserve to be considered one of the league’s best teams.

“This game is like no other,” defensive end Cory Redding said. “The Texans are a great opponent. These guys have great weapons on both sides of the ball. They’ve been doing some unbelievable things this year, and we’ve got our hands full. Like you said, the Colts used to own this division for many years, so it’s time to go ahead and get that thing back.”

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