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Her first-round loss mirrors that of Petra Kvitova, who went out in the first round of last year’s U.S. Open after winning Wimbledon.

The second-ranked Kvitova advanced this time, winning the last 12 consecutive in a 6-2, 6-0 romp over Vera Dushevina of Russia.

No. 4-ranked Maria Sharapova won the first eight games of a 6-0, 6-1 rout of Gisela Dulko of Argentina.

Stosur is gone, but fans hung around to watch another Aussie hope. Hewitt, a two-time major winner and former Australian Open finalist, gave the night session crowd something to cheer when he beat Cedrik-Marcel Stebe of Germany 7-5, 6-4, 3-6, 7-5, winning the last six games to overcome two service breaks in the last set.

Hewitt’s win put him into a second-round match against old rival Andy Roddick, who easily defeated Robin Haase of the Netherlands 6-3, 6-4, 6-1.

Defending champion and top-ranked Novak Djokovic dropped an early service game before winning the last 17 games to beat Paolo Lorenzi of Italy 6-2, 6-0, 6-0. Both the men he has beaten in Australian finals also advanced. Andy Murray, runner-up the last two years, defeated American teenager Ryan Harrison 4-6, 6-3, 6-4, 6-2. Sixth-seeded Jo-Wilfried Tsonga, beaten by Djokovic in the 2008 final, eliminated Denis Istomin 6-4, 3-6, 6-2, 7-5.

Rafael Nadal, the 2009 Australian Open champion, and four-time winner Roger Federer were playing later Wednesday.

Federer makes a rare departure from Rod Laver Arena, playing his second-round match against Andreas Beck in the last match on Hisense Arena, the second show court at Melbourne Park. It will be the first time since a second-round win over American qualifier Jeff Morrison in 2004 that Federer hasn’t played an Australian Open singles match on Rod Laver Arena.