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He will play Kei Nishikori, the first Japanese man to reach the fourth round in Melbourne in the Open era. Mikhail Kukushkin, who beat an ailing Gael Monfils in five sets, will be the first man from Kazakhstan to play a Round of 16 match at a Grand Slam when he faces Murray.

Williams is frequently the only American left in a tournament, and it doesn’t bother her.

“I really don’t think when I go out there that I’m the last American,” she said. “I just think I’m trying to come in here and win this match, play this girl. That’s all I really think about.”