- Associated Press - Wednesday, October 17, 2012

NEW YORK (AP) - NFC Worst? Not anymore.

That was so 2010. Here in 2012, the NFC West is the best division in all of pro football.

And the two best teams in the division, the San Francisco 49ers (No. 5 in the AP Pro32) and Seattle Seahawks (No. 9) face off in the city by the bay on Thursday night.

Even though they come off their worst performance of the season in a 23-3 home loss to the Giants, the Niners are 7-point favorites _ despite the Seahawks coming off a stirring comeback victory against New England.

You’ve got to dust yourself off and ride,” 49ers coach Jim Harbaugh said. “Right now we have no choice. We have to get to Seattle right quick. We’ve got a football fight coming.”

Much of that fight figures to be on the ground. Marshawn Lynch leads the NFC in rushing and is third in the league with 549 yards. Last year, he gained 107 against the 49ers and snapped San Francisco’s string of 36 successive games not allowing a 100-yard gainer.

“Their running game is the bread and butter of their offense,” Niners defensive coordinator Vic Fangio said. “And everything works off of that. He’s one of the best backs in the league. He’s the best back we played last year by far. He broke more tackles than any back we played against last year. He broke the most against us.”

For Seattle to pull slightly ahead in the NFC West race _ the Seahawks, 49ers and Cardinals are all 4-2; the Rams are 3-3 _ it must stymie the 49ers’ running game. Frank Gore has 470 yards rushing and a 5.4-yard average, better than Lynch’s 4.3.

With the way Alex Smith struggled against a Giants defense that hadn’t been all that impressive beforehand, the Seahawks could present a huge challenge to San Francisco’s passing attack at Candlestick Park.

Then again, the Niners need to prove something to themselves _ and to the rest of the league.

49ERS, 27-14

No. 21 New York Jets (plus 10 1/2) at No. 8 New England

Patriots are angry at themselves _ and they always are angry with the Jets.

BEST BET: PATRIOTS, 37-13

No. 15 Pittsburgh (minus 2 1/2) at No. 20 at Cincinnati

Story Continues →