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Other regions could see their share of hits, too.

A $490 million cut at the Centers for Disease Control and Prevention would hurt in Atlanta, where the CDC is based, while NASA faces about $1.5 billion in cuts.

The sequesters have become a major political issue in this election year.

Republicans accused Mr. Obama of being the architect, and say he is to blame for the fact that they fall so heavily on defense.

Mr. Obama, meanwhile, pointed to Republicans who called the debt deal a success.

Both sides have said they never intended the cuts to take effect, but they have been unable to agree on a way to replace them.

Last year’s supercommittee failed, and since then both sides have dug in, with the GOP saying domestic spending should see a deeper cut so defense spending can be spared, and Democrats saying taxes must be raised to preserve worthy programs.

D.C. Council member Jack Evans said his city is already planning to do without the money in next year’s budget but that he does not expect citizens will be able to adjust so easily.

“It’ll be the working-class and middle-class people who suffer the most,” said Mr. Evans, a Democrat. “I don’t know where the compromise is going to come, to be honest with you.”

Tom Howell Jr. contributed to this report.