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“We’ve seen it now,” Colbert said. “If we do see trends and we see bets, we’ll move more aggressively than we did in the past.”

Teams normally get a 3-point edge factored into the line when they play at home. That home edge could be worth a half-point more with games refereed by replacement officials, depending on the game, Colbert said. Colbert said he believed the Monday night referees got caught up in the excitement of Seattle’s home crowd.

“I’d be willing to make a big bet that if that game is in Green Bay, that play is overturned and they win it,” he said.

Bettors are also reacting. Wong said he’s wagering 20 percent less on NFL games than usual because of the unpredictability of the referees and other factors. He said his friends are cutting their bets in half or talking about avoiding NFL wagers for a few weeks if the replacement officials stay in.

“I’m willing to put less at risk at this point,” Wong said. “I’m not motivated to put that much on the table.”

Johnny Avello, race and sports director at the Wynn Las Vegas hotel-casino, said plays _ and mistakes _ happen each week throughout the year that decide the outcomes of bets. But this moment was magnified, he said, because it happened at the end of the game and the call single-handedly decided the outcome.

“If you’re a bettor, it’s going to be hard to get over,” he said. “Some may back off, and that’s yet to be seen.”

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Garcia reported from Honolulu. He can be reached on Twitter at http://twitter.com/oskargarcia