Matt Guerrier (1-0) retired the only batter he faced, getting Jesus Guzman to fly out to end the seventh with runners on first and second. Kenley Jensen pitched the ninth for his first save.
Former San Diego star Adrian Gonzalez hit a two-run homer deep into the seats down the right-field line with two outs in the first off Marquis, his first. Carl Crawford was aboard on a leadoff single.
Marquis allowed two runs and seven hits in five innings, struck out five and walked four.
NOTES: The Dodgers took two of three from the Padres. … L.A. heads to Arizona for a three-game series starting Friday night, with LHP Clayton Kershaw (2-0, 0.00 ERA) scheduled to face LHP Patrick Corbin (1-0, 3.00). The Padres open a three-game home series against Colorado, with RHP Tyson Ross (0-1, 4.50) scheduled to face RHP Jon Garland (1-0, 3.00). … Andre Ethier singled in the seventh to extend his hitting streak to 11 games. … Greinke reached 1,500 career innings. … The Padres dropped to 2-7, matching last year’s start.