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The brutal clerical regime in Iran is on the defensive, making this a time to push further for the fall of Mr. Assad and to increase sanctions and pressure against the Tehran regime. Once and for all, we must remove the masters of worldwide terrorism before they become nuclear-armed, which would indeed be a game-changer — with the world as its hostage.

Reza Kahlili is a pseudonym for a former CIA operative in Iran’s Revolutionary Guard and author of the award-winning book “A Time to Betray” (Simon & Schuster, 2010).