Sproles headed to the locker room early in the first quarter, and the Saints announced he was out for the rest of the game shortly before halftime.
New York also lost a key player on offense when wide receiver Jeremy Kerley was knocked out of the game with an elbow injury in the second quarter.
Kerley, the team’s leading receiver, appeared to be hurt when he was on the ground after a running play. New Orleans’ David Hawthorne hit Kerley’s left arm, which rolled awkwardly under the linebacker’s shoulder. Kerley immediately grabbed at his arm, was checked by trainers on the sideline and then headed to the locker room.