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Cain allowed four hits over seven innings with eight strikeouts and three walks. He is winless in his last seven starts at AT&T; Park.

“I was throwing a lot of strikes and the ball was moving around quite a bit,” Cain said. “But they got a leadoff walk and I did a bad job of keeping (Blackmon) on.”

Tulowitzki went hitless in three at-bats in his return to Colorado’s lineup after sitting out the series opener with a sore quad. Catcher Wilin Rosario was also back after resting a sore hand on Friday.

Even at full strength, the Rockies needed a big lift from their bullpen to pull this one out.

Anderson lasted just three innings after bruising the index finger on his left hand apparently while grounding out to end the top of the fourth. Anderson took the mound to begin the bottom of the frame before a team trainer was summoned from the dugout.

“It felt like a firecracker went off in my glove,” Anderson said. “I went out there and threw a warmup pitch and it felt like what I envision trying to throw with a foam finger feels like.”

Anderson eventually walked off the field and was replaced by Kahnle.

Sandoval greeted the Rockies reliever with a double to the gap in left-center on Kahnle’s first pitch after center fielder Blackmon missed on a diving attempt. After Buster Posey walked, Kahnle got Mike Morse to ground into a double play and struck out Hector Sanchez.

The Giants couldn’t do much else, spoiling Cain’s strongest outing of the season.

NOTES: Gonzalez went 0 for 4, ending his 10-game hitting streak. … RHP Tyler Chatwood makes his season debut for the Rockies in the series finale on Sunday. RHP Tim Hudson (2-0) goes for San Francisco. … Danielle Meulens, daughter of Giants hitting coach Hensley Meulens, sang the national anthem.