Arkansas lab conducts research on living lungs

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LITTLE ROCK, Ark. (AP) - With his left hand on the edge of a microscope and his right hand tapping commands into a keyboard, cell biologist Dr. Richard Kurten nods to the computer screen.

The tissue under the microscope - a live, human lung - is reflected as a dark oval outlined with what look like tiny bubbles, pulsing to the rhythm of a beating heart.

“There’s something special about life. I’m a scientist and I try to break things down, but this is just incredible,” Kurten, a University of Arkansas for Medical Sciences researcher who has spent the majority of his nearly two-decade career studying respiratory biology, specifically the effects of asthma medications on the lungs, told the Arkansas Democrat-Gazette (http://bit.ly/1gH2AnV).

Kurten’s small laboratory at the Arkansas Children’s Hospital Research Institute - which is supported in large part by proceeds from the Arkansas Tobacco Settlement - is one of only about five in the nation and about 10 in the world that conduct research on living lungs harvested from deceased human donors.

Kurten - who still uses a green chalkboard to map out his formulas - pointed to the corner of the lab where a cardboard box, stamped with “Left Lung,” sat on the floor.

Much like those on a transplant list, Kurten has to be ready at a moment’s notice for the call that a lung has become available. The organs - which usually come in pairs about the size of a half-gallon milk jug - are sent to Kurten’s lab only after they have been deemed not viable for transplant.

“I meet them at the airport usually. Sometimes they bring them to my house. Friday evenings are usually when we get them. Christmastime tends to be the busiest,” Kurten said.

Kurten became involved in the groundbreaking approach three years ago when a pharmaceutical company asked if his research findings could be replicated in humans instead of rats - which had been the only option outside of actual human trials.

That was when Kurten contacted Dr. Reynold Panettieri Jr., director of Airways Biology Initiative at the Perelman School of Medicine at the University of Pennsylvania. Panettieri, who was in the very early stages of using the live, human lungs, supplied Kurten with his first test samples.

The two scientists quickly formed a collaboration that grew to an invitation from Panettieri for Kurten - as well as the Thomas Jefferson University in Philadelphia, the University of South Florida in Tampa and Johns Hopkins University in Baltimore - to participate in an $11.9 million research grant from the National Institutes of Health.

The five-year grant awarded last year supports the group’s human-lung research on asthma and chronic obstructive pulmonary disease.

“We had interesting results,” Kurten said. “We found out, ‘You know what? Rats are different from humans.’”

The use of human lungs is as close as a scientist can get without resorting to costly and potentially dangerous trials on human volunteers, Panettieri said.

“The rats do not typically mimic the disease in humans. This bridges the gap,” Panettieri said.

Kurten further humanizes his research by consulting with Dr. Stacie Jones, chief of pediatric allergy and immunology at UAMS. Jones gives Kurten real-time feedback on the issues and effects of medications she sees in her patients.

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