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The Mariners broke it open with four runs in the sixth, as Stefan Romero greeted Fernando Salas with an RBI double and Zunino hit his sixth big league homer. Smoak and Hart both homered with two outs in the ninth against Ernesto Frieri.

NOTES: Santiago’s only other start at Angel Stadium came with the White Sox on May 18, 2013, when he allowed three runs and four hits over 3 1-2 innings in a no-decision. … The Angels begin a four-game series Friday night at Houston. The Astros won the season series 10-9 last year, despite finishing a major league-worst and franchise-worst 51-111 after switching over from the NL to the AL. … Angels pitchers gave up 17 extra-base hits and 15 walks in the series.