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Enroth made a glove save of Matt Irwin’s slap shot through traffic with under seven minutes to play to keep Buffalo ahead. He made another strong glove save 7:22 into the second period when Marleau was left uncovered in the slot.

“It was kind of late notice,” Enroth said of getting the word he was starting, “but I just told myself to relax, go out there and compete.”

Moments after Enroth stopped Marleau, Myers beat Niemi off a rush up the right side, but his shot clanked off the cross bar.

After another pair of saves, Enroth was beaten when Sheppard forced a puck between the goaltender’s legs after a shot rebounded off the end boards.

The Sharks finished the second period with a 31-13 advantage in shots on goal.

“We knew they’d be ready,” Sharks center Joe Pavelski said. “We had our chances to score early and we didn’t, fell behind, climbed back and just didn’t turn the corner like we needed to.”

Buffalo restored its lead 4:33 into the third when Zemgus Girgensons won a faceoff back to Flynn, whose wrist shot beat Niemi.

The Sabres doubled their advantage four minutes later when Myers jumped into the play from the right point to feed Moulson in the slot, who scored over Niemi’s shoulder.

Marleau brought the Sharks within one with a one-timer with 1:15 left in regulation. Joe Thornton picked up his 50th assist of the season on the goal.

“They played hard,” Thornton said of the Sabres. “Obviously, I’m sure a lot of feelings over there with two teammates. it’s a tough business, but they played well tonight.”

Myers added an empty-net goal with 21 seconds left to give him a goal and two assists on the night.

Tyler Myers is really starting to come into his own,” Nolan said. “I thought he was sensational tonight.”

NOTES: Tyler Ennis missed his second straight game for Buffalo with “undisclosed soreness” … San Jose LW Raffi Torres was scratched after scoring two goals in his season debut Thursday