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Wawrinka, who lost 12-10 in the fifth set to eventual champion Novak Djokovic in the fourth round here last year in the longest Grand Slam match of 2013, was leading 6-4, 6-1 when his Kazakhstan rival quit. Two other players retired due to shoulder injuries, with Alex Bogomolov Jr., quitting after losing two sets to No. 15 Fabio Fognini and No. 12-seeded Tommy Haas pulling out when he was down a set and a break against Guilllermo Garcia-Lopez.

Third-ranked David Ferrer opened with a 6-3, 6-4, 6-4 win over Colombia’s Alejandro Gonzalez on Rod Laver Arena and No. 7 Tomas Berdych beat Aleksandr Nedovyesov of Ukraine 6-3, 6-4, 6-3.

Other men advancing included No. 9 Richard Gasquet, No. 14 Mikhail Youzhny, No. 19 Kevin Anderson, No. 23 Ernests Gulbis, No. 29 Jeremy Chardy, No. 32 Ivan Dodig, who beat fellow Croatian Ivo Karlovic 7-6 (8), 6-3, 7-6 (4), and American Sam Querrey, who defeated Santiago Giraldo of Colombia, 6-3, 6-2, 3-6, 7-6 (3).