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“Tom is having a tough time getting through that sixth inning,” Marlins manager Mike Redmond said. “He was breezing. He’s got to fight through that to win games at this level.”

The Marlins responded in the bottom half of the sixth. Marcell Ozuna led off with a triple and scored on a sacrifice fly by Adeiny Hechavarria.

Hammel allowed four runs and eight hits. He struck out nine in six innings.

Giancarlo Stanton put the Marlins on the board in the first inning with his 19th home run, a two-run line drive that just cleared the right field wall.

“I could not get the slider down and that was the ball that Stanton hit,” Hammel said. “I’ve never seen a home run like that. I think it took two seconds to get out of the ballpark. I thought it was going to be a foul ball and hitting the base of the wall or something. That’s impressive.”

Miami padded its lead in the third when Stanton scored on Casey McGehee’s single to right.

The Marlins failed to convert with the bases loaded in the seventh. Garrett Jones grounded into a forceout at home and Ozuna struck out looking.

NOTES: The Marlins observed a moment of silence for Hall of Famer Tony Gwynn, who died Monday. … The Cubs improved to 3-6 in extra inning games this season. The Marlins fell to 4-6. … Castro registered his 11th three-hit game and now shares the major league lead in the category with Colorado’s Troy Tulowitzki. With his home run in the sixth, Castro picked up his eighth extra-base hit in his last 10 games. … The Cubs intentionally walked Stanton in the 11th inning, giving the Marlins slugger 14 intentional passes this season. Stanton trails only Boston’s David Ortiz (15) in intentional walks. … Jake Marisnick and Justin Bour, both recalled from Triple-A New Orleans, saw action in Monday’s game. Marisnick batted leadoff in place of the injured OF Christian Yelich and finished 2 for 6 with run, a walk and two stolen bases. Bour struck out in a pinch-hit appearance for Koehler in the sixth inning, … The teams continue the series Tuesday night, with Chicago RHP Jeff Samardzija (2-6) facing RHP Anthony DeSclafani (1-1).