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An arbitrator would be allowed to reduce a suspension for a first or second testing violation by up to 50 percent if a player proves by “clear and convincing evidence” that a positive test was not caused by his “significant fault or negligence.” However, penalties may not be cut for muscle-building substances such as testosterone, human growth hormone, Boldenone, Nandrolone and Stanozolol.

In-season random urine tests will increase from 1,400 to 3,200 overall in addition to the minimum two for each player, and offseason tests will rise from 250 to 350.

There will be 400 random blood collections used to detect human growth hormone in addition to the mandatory one for each player during spring training.

“We want to have a level playing field,” Los Angeles Dodgers first baseman Adrian Gonzalez said.

Players with PED violations, other than those who penalties are reduced for mitigation, will receive six additional random urine tests and three more blood tests annually for the rest of their careers. Foreign players entering the major leagues and those not subject to the major- or minor-league testing program for at least a year will be required to take urine and blood tests before signing contracts.

“There are certain considerations we need to make in an effort to put guys in a position where the guys who are doing it correctly aren’t being adversely affected any more than necessary,” Clark said.

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AP Baseball Writer Janie McCauley and AP freelance writer Mike Cranston contributed to this report.