- Israel hits symbols of Hamas rule; scores killed
- Mississippi abortion law can’t be enforced
- Teacher who survived Sandy Hook has book deal
- Jury awards Jesse Ventura $1.8M in case vs. ‘American Sniper’ author Chris Kyle
- Middle Eastern firm’s deal to manage U.S. cargo port raises security concerns
- Bob McDonnell’s defense: Lonely wife developed ‘crush’ on CEO
- Chinese hackers stole ‘huge quantities’ of sensitive data on Israel’s Iron Dome
- House Republicans unveil bill to speed deportations of border children
- Californians protest middle school for hiring white man to teach cultural studies
- Killer’s sentencing overturned because mother couldn’t find seat in courtroom
Doctors hope for cure in a 2nd baby born with HIV
Question of the Day
HIV usually infects blood cells through a protein on their surface called CCR5. A California company, Sangamo BioSciences Inc., makes a treatment that can knock out a gene that makes CCR5.
Dr. Carl June at the University of Pennsylvania tested it in 12 HIV patients who had their blood filtered to remove some of their cells. The treated cells were infused back into the patients.
Four weeks later, half of the patients were temporarily taken off AIDS medicines to see the gene therapy’s effect. The virus returned in all but one of them; that patient turned out to have one copy of the protective gene.
“We knew that the virus was going to come back in most of the patients,” but the hope is that the modified cells eventually will outnumber the rest and give the patient a way to control viral levels without medicines, said Dr. Pablo Tebas, one of the Penn researchers.
The National Institute of Allergy and Infectious Diseases sponsored the work with Sangamo and Penn.
“The ultimate goal is to create an immune system in the body that’s been edited genetically so the cells are not capable of being infected with HIV,” said director Dr. Anthony Fauci, “but we are a long way from there at this point.”
Jay Johnson, 53, who works for Action AIDS, an advocacy and service organization in Philadelphia, had the treatment more than three years ago. Although the virus rebounded when he temporarily went off HIV medicines, tests show his modified blood cells are still multiplying.
“Hopefully one day I’ll be able to say I’m HIV negative again,” he said.
AIDS information: http://www.aidsinfo.nih.gov
Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP
TWT Video Picks
- Boehner rules out impeachment: 'Scam started by Democrats'
- Obama thanks Muslims for 'building the very fabric of our nation'
- Obama's brother wears Hamas scarf bearing anti-Israel slogans in photo
- Tactical advantage: Russian military shows off impressive new gear
- Federal judge grants 90-day stay in D.C. gun case
- McCLAUGHRY: Finish off the "Islamic State" quickly and cheaply
- New York Times reporter Carol Vogel accused of plagiarism
- Iraqi Christians rally at White House: 'Obama, Obama, where are you?'
- Hillary Clinton: Forget Obama, George W. Bush made her 'proud to be an American'
- ISIL destroys key bridge leading to Baghdad; suicide truck bomb severed supply line
Obama's biggest White House 'fails'
Celebrities turned politicians
Athletes turned actors
20 gadgets that changed the world