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Andre Rienzo (4-2) struggled to keep the Padres off base and consistently ran into trouble. He lasted only 3 1-3 innings, surrendering three runs on seven hits.

Twice the White Sox cut the Padres‘ lead to one run, but they could never pull closer.

Dayan Viciedo’s two-out double to right-center field scored Adam Eaton, who reached on an error by shortstop Everth Cabrera to start the fifth, to cut the Padres‘ lead to 3-2.

San Diego made it 4-2 in the sixth on Alexi Amarista’s sacrifice fly.

Paul Konerko’s single in the second snapped his 0-for-12 stretch and put runners on the corners for the White Sox after Alexei Ramirez led off the inning with a single. A run scored when Alejandro De Aza grounded into a double play.

The Padres loaded the bases with no outs in the third. Venable hit an RBI single to center field, and Eaton threw out Carlos Quentin at the plate, keeping San Diego’s lead at 3-1.

A diving catch by Padres right fielder Chris Denorfia to end the fourth on Tyler Flowers’ line drive preserved the lead.

NOTES: Konerko returned to the White Sox lineup after missing the last two games because of back trouble. He went 1 for 4.