- Associated Press - Wednesday, May 11, 2016

HOUSTON (AP) - After Cody Anderson’s start was pushed back this week because of Cleveland’s off day on Thursday, manager Terry Francona said the right-hander might make an appearance out of the bullpen.

It’s safe to say Francona didn’t envision using Anderson after he’d exhausted all his relievers through 12 innings of what would be a 16-inning game against the Houston Astros on Wednesday.

Marwin Gonzalez hit a two-run homer off Anderson (0-3) in the 16th to give the Astros a 5-3 win over the Indians.

Carlos Correa reached on an infield single to start the inning, Houston’s first hit since the seventh. One out later, Gonzalez sent one into the seats in right field to hand Houston its third victory in five games.

“You get into an extra-inning game on the road, you’re a pitch away from going home,” Francona said. “That hurts, but really pleased with the way he attacked with his pitches. … He’s going to be OK.”

Michael Feliz (1-0) allowed one hit in three scoreless innings for the win.

Anderson yielded two hits, two runs and struck out four over 3 1/3 innings in his first career relief appearance.

“Different situation but still the same thing. Just have to get outs,” he said. “Unfortunately today, they wanted me to win and didn’t come through.”

Francona wasn’t worried about leaving Anderson out there too long because he’s a starter who is scheduled to go for the Indians on Monday.

“He’s fine,” Francona said. “He could have pitched for a while.”

The game matched Washington’s 6-5 victory over Minnesota in 16 innings on April 24 for the longest in the majors this season.

The teams combined to use 18 pitchers who threw 489 pitches in an endurance test that lasted 5 hours, 9 minutes. Cleveland used nine relievers after starter Danny Salazar was replaced after five innings. Houston sent out seven relievers after Doug Fister was lifted to start the eighth.

The Indians fanned 18 and walked 12, both season highs.

“I feel like I pitched yesterday,” Salazar said. “That was awesome, though. Cody wasn’t even supposed to pitch today. He made that sacrifice there and he saved a few arms.”

Houston went 2 for 15 with runners in scoring position and left a season-high 17 runners on base.

The Indians got a pair of singles in the 10th and one in the 11th, 13th and 16th but stranded all those runners.

Cleveland’s Mike Napoli doubled with one out in the ninth and scored on a triple by Carlos Santana that rolled up Tal’s Hill in center field to tie it at 3 and send the game to extra innings.

Jason Kipnis tied a career high with five hits and had an RBI, and Napoli hit a solo home run to put Cleveland up 2-0 in the fourth.

The Astros had plenty of baserunners early but weren’t able to score until George Springer’s solo homer in the fourth inning. They tied it in the sixth on an RBI single by Correa.

Springer walked a career-high four times.

Preston Tucker’s RBI single put Houston up 3-2 in the seventh, but the Astros didn’t get another hit until Correa’s in the 16th.

Springer snapped an 0-for-12 skid when he hit Houston’s 1,500th home run in Minute Maid park off Salazar, a solo shot that cut the lead to 2-1 with two outs in the fourth. Jose Altuve doubled with two outs in the sixth before a walk by Springer. The single by Correa sent Altuve home to tie it at 2.

Fister yielded six hits and two runs in a season-high seven innings. Luke Gregerson allowed the run in the ninth for his first blown save this season.

Salazar gave up four hits and one run while fanning a season-high 10 in five innings.

TRAINER’S ROOM

Indians: Michael Brantley, coming off shoulder surgery in November, was feeling better after getting a day off Tuesday. Brantley was also off Wednesday and Francona said the outfielder will be re-evaluated Friday after the team’s day off to see if he’s ready to return to the lineup.

UP NEXT

Indians: Josh Tomlin (5-0, 3.72 ERA) starts the opener of a series against Minnesota on Friday. Tomlin has won each of his last six starts dating to last season, and 12 of 14 decisions.

Astros: Last year’s AL Cy Young Award winner, Dallas Keuchel (2-4, 4.70), tries to get back on track Thursday night in Boston after four tough starts. Keuchel hasn’t won since April 15, going 0-3 with a 6.94 ERA since then. He’ll face another struggling ace in Red Sox lefty David Price (4-1, 6.75), the 2012 AL Cy Young winner.

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