Fresh off a second straight drubbing of the once-mighty Barcelona, Bayern Munich was voted the top team in the Associated Press global soccer poll for the sixth straight week.
Marco Reus and Felipe Santana scored in second-half stoppage time during an incredible comeback, and Borussia Dortmund advanced to the Champions League semifinals for the first time in 15 years.
Barcelona received the maximum points in AP's global soccer rankings on Tuesday, with the team's striker, Lionel Messi, coming close to top marks.
Cristiano Ronaldo surged to the top of the AP's latest global soccer rankings on Tuesday, thanks to decisive goals for Real Madrid in La Liga and the Champions League.
The forward completed Madrid's comeback in the 69th minute to secure a 3-2 aggregate win after the Spanish champions took advantage of United being reduced to 10 men.
Two victories in four days over rival Barcelona propelled Real Madrid to first place in the AP global soccer rankings.
With Madrid trailing Barcelona by 16 points in the Spanish league, the pressure is on Mourinho to deliver success in Europe and win the continent's most glittering prize for the club for the 10th time.
Lionel Messi's four-goal burst ensured that he and Barcelona returned to the top of the Associated Press Global Soccer rankings this week.
Lionel Messi and Barcelona fell from the top of the Associated Press Global Football Rankings this week and were replaced by rivals Cristiano Ronaldo and Real Madrid.