Harbaugh also has an opportunity to prove he meant business when he said domestic violence wouldn't be tolerated on his team.
SNYDER: Ray McDonald's stupidity gives Roger Goodell convenient outlet for outrage →
"We have to tighten this down fast," coach Jim Harbaugh said. "We have work to do, there's no doubt about it."
Peyton Manning, Broncos rout 49ers to open Levi's Stadium →