- The Washington Times - Wednesday, August 20, 2003

BOSTON — A major study of heart attacks shows emergency angioplasties work so much better than drugs that they are usually worth the wait of a hospital transfer — a finding that could reshape guidelines for the 1.1 million Americans who suffer heart attacks each year.

Now, most heart attacks are treated only with clot-busting drugs, which can be given anywhere. Most hospitals cannot do quick artery-clearing angioplasties, and doctors are reluctant to postpone treatment while patients are moved to hospitals that can.

However, the large Danish study recently published in the New England Journal of Medicine concludes that a transfer to an angioplasty center cuts the risk of death and major complications by about 40 percent.

Comparing 1,129 patients with major heart attacks, 14 percent either died or had another heart attack or disabling stroke when treated with drugs alone during the monthlong study. Only 8 percent died when transferred to another hospital for angioplasty. Nearly all were transferred within two hours.

“I think the study is very provocative and needs to make us think about transferring patients, but very carefully and very thoughtfully,” said Dr. Alice K. Jacobs, who performs angioplasties at Boston University Medical Center and wrote an accompanying editorial.

The question of transfers potentially affects hundreds of thousands of patients. In the United States, heart attacks kill about 460,000 yearly, according to the National Institutes of Health.

They develop when clogged and clotted arteries crimp the stream of blood to heart muscle. During angioplasties, doctors snake skinny tubes tipped by plastic balloons into the blocked arteries and then inflate them, restoring blood flow. Angioplasties are generally preferred to drugs alone for emergency treatment of heart attacks.

Several factors have limited angioplasties, though. They require sophisticated surgical backup in case something goes wrong. Clot-dissolving drugs like TPA can be given by emergency room doctors. Only about 20 percent of heart-attack patients undergo angioplasties, and only about 15 percent of hospitals can perform them, doctors estimated.

In recent years, several studies have begun to suggest that the benefits of angioplasties might outweigh delays for hospital transfer. The Danish study helps settle the question, some doctors said.

Still, it isn’t yet clear how many patients, especially in the United States, can be transferred as quickly as the ones in the Danish study, doctors said.

“We are not geared up as a nation to deal with things as Denmark was able to,” said Dr. Howard Levite, a cardiologist at Atlantic City Medical Center in New Jersey.

Also, even in the nationalized Danish health system, the researchers took special precautions that ordinary hospitals might not take. Potential transfers were whisked past emergency rooms straight to a cardiac care team. Four percent of patients were ruled out for the study, because doctors felt they were unable to tolerate the transfer.

“I need to know that the transport system is going to be rapid and effective if the patients are sent,” said Dr. Sidney Smith, a cardiologist at the University of North Carolina who is a past president of the American Heart Association.



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