- The Washington Times - Wednesday, October 6, 2004

STOCKHOLM — Two Israelis and an American won the Nobel Prize in chemistry yesterday for showing how cells can give a “kiss of death” to destroy unwanted proteins, a finding that could help scientists find new medicines for cancer and other diseases. The award marks the first time any Israeli has won a Nobel science prize.

Israelis Aaron Ciechanover and Avram Hershko, and American Irwin Rose were cited for revealing a process that gives doomed proteins a chemical label and then chops them up.

That process in turn governs such key tasks as cell division, DNA repair and quality control of newly produced proteins, the Royal Swedish Academy of Science said in awarding the prize. If it goes wrong, diseases like cervical cancer can result, the academy said.

Mr. Ciechanover, 56, is the director of the Rappaport Family Institute for Research in Medical Sciences at the Technion in the port city of Haifa, Israel, while Mr. Hershko, 70, originally from Hungary, is a professor there. The 78-year-old Mr. Rose is a professor emeritus at the University of California at Irvine.

The three will share the $1.3 million cash prize for their work, done in the 1980s.

At a news conference in Mr. Hershko’s apartment in Haifa, the two Israelis said they hope their work will lead to advances in the treatment of cancer.

One such drug, Velcade, is on the U.S. market, Mr. Ciechanover noted, and “there are many more in the pipeline.”

Added Mr. Hershko: “It does not mean that a miracle drug to beat cancer is on the way. But I do believe there will be advances in the treatment of cancer based on our work. This I truly believe in.”

The protein-destroying process the scientists discovered was completely unexpected, because scientists had thought such destruction was not regulated, said Lars Thelander, a member of the Nobel Committee for Chemistry.

Mr. Thelander said researchers now hope they will be able to manipulate the protein-degradation system in two different ways — either to prevent it from destroying proteins that boost the immune system, or to get rid of proteins that help cause diseases.

“And we hope also that by knowing this system in detail we will be able to make new medicines,” he said.

Mr. Hershko and Mr. Ciechanover said they were proud to be the first Israelis to win Nobel prizes for science.

“We’re a small country … so we don’t have all the infrastructure that big laboratories have in the U.S. or in other places,” said Mr. Hershko.

The prize is “identified 100 percent with Israeli scientists that … have worked and lived in the country and will continue to live and to work in this country,” added Mr. Ciechanover.

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