- The Washington Times - Monday, April 28, 2008

LOS ANGELES (AP) — The number of pregnant women with pre-existing diabetes has more than doubled in seven years, a California study found — a troubling trend that means health risks for both mothers and newborns.

And the number of diabetic teenagers giving birth grew fivefold during the same period, according to the study, the largest of its kind.

Expectant mothers who don’t control their diabetes face an increased risk of miscarriage and stillbirth. Their babies have a higher chance of being born with birth defects.

“These are high-risk pregnancies,” said Dr. Florence Brown, an expert on pregnancy and diabetes. “All women with pre-existing diabetes need to plan their pregnancies.”

Dr. Brown is co-director of the Joslin Diabetes Center/Beth Israel Deaconess Medical Center diabetes and pregnancy program in Boston. She had no role in the study, which was done by researchers at Kaiser Permanente, a California-based health care provider.

The researchers focused on health records from more than 175,000 ethnically diverse women who gave birth in a dozen Kaiser hospitals in Southern California from 1999 to 2005. Experts say the findings likely reflect the overall U.S. population.

The actual number of pregnant women with pre-existing diabetes was small. In 1999, there were 245 such women; by 2005, there were 537. That translates to a rate that rose from 8 per 1,000 pregnancies to 18 per 1,000.

The diabetes prevalence was highest among 13- to 19-year-olds giving birth. The rate ballooned from about 1 per 1,000 pregnancies to 5.5 per 1,000 during the seven-year period.

Blacks, Asians and Hispanics were more likely to have pre-pregnancy diabetes than were whites.

The rise of diabetes among women of childbearing age mirrors the prevalence of the disease in the general population. The most common form of diabetes is Type 2, which is linked to obesity.

About 15 million people in the U.S. are diagnosed with diabetes, and 1.5 million new cases were diagnosed in people 20 and older in 2005, according to the American Diabetes Association.

Pre-pregnancy diabetes is different from gestational diabetes, which is developed during pregnancy and disappears later. Gestational diabetes affects 3 percent to 8 percent of pregnant women in the U.S.

In the study, Kaiser researchers did not look at whether any of the women had prenatal diabetes care or how the babies fared after birth. They also could not determine the type of diabetes that the women had.

Type 2, which is linked to obesity, occurs when the body makes too little insulin or cannot use what it does produce. Type 1 occurs when the body doesn’t produce insulin.

Results of the study were published online today in the journal Diabetes Care, a publication of American Diabetes Association, which funded the research.

“There are things women can do before they become pregnant that will increase the likelihood of them having a healthy baby,” said lead author Jean Lawrence, a research scientist with Kaiser Permanente Southern California.

That includes controlling blood sugar levels with an insulin pump or maintaining a healthy diet and exercise routine.

Michelle Cangemi, who has Type 1 diabetes, was among those who sought care before she become pregnant with her first child in 2005.

“It was definitely something that worried me throughout my pregnancy,” said the 29-year-old dietitian whose daughter turned out healthy. “You don’t know how the blood sugar levels are going to affect a child that’s developing.”

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