Parents push to limit use of antidepressants

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Parents pleaded with the Food and Drug Administration yesterday to end the use of popular adult antidepressants on children, saying the drugs can increase youths' risk of suicide and violence.

"To die in this violent, unusual fashion without making a sound ... Paxil must have put her over the edge," said Sara Bostock, describing how her daughter Cecily stabbed herself in the chest with a kitchen knife shortly after graduating from Stanford University and two weeks after starting the drug.

Another parent agreed.

"You have an obligation today ... from preventing this tragic story from being repeated over and over again," said Mark Miller of Kansas City, Mo., whose son Matt hanged himself in his bedroom closet after taking his seventh Zoloft tablet.

But countering those complaints were a handful of families who say the class of antidepressants known as SSRIs have changed their children's lives by alleviating serious depression.

"My children have had tremendous improvement with their illnesses," said Dr. Suzanne Vogel-Scieilia of the National Alliance for the Mentally Ill, who has two sons using the drugs. "I shudder to think of their plight if these medicines were not available."

The FDA is examining whether the suicide risk is real, and if so, what to do. It's a difficult decision because depression itself can lead to suicide.

Among 25 studies of the suspect medications involving 4,000 young people, there were no suicides. But 109 patients experienced one or more suicide-related behaviors or attempts, FDA medical reviewer Dr. Thomas Laughren said yesterday.