No cause for Tamiflu terror

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Feathers are flying anew over so-called "bird flu." Researchers have reported the deaths of four Vietnamese patients suffering from it and treated with an antiviral drug. Perhaps two received it too late, but the others had resistance to the medicine. The drug? Roche's Tamiflu, which the media have anointed with almost mythical properties.

But if this has you running around like an infected chicken with its head cut off, stop it. You're scaring the eggs.

The first reason not to panic over Tamiflu is there's no reason to panic over a pandemic.

It's true avian influenza type H5N1 is constantly mutating. But the best-kept secret of the flu fright-fest is that it's been doing so since at least 1959 when it was identified in Scottish chickens. Despite unsupported claims from the World Health Organization that it will almost inevitably become transmissible from human-to-human, if it hasn't yet it probably never will. If it did, it wouldn't let media hysteria dictate its appearance and fall on us before effective vaccines are widely available.

As to that resistance, this almost always means simply more of the drug must be administered than previously required. Health officials say that applies here.

Granted, since there's already a shortfall of Tamiflu, it's bad if we'll need even more. But that's a lot better than finding Tamiflu's only purpose now would be as landfill to build New Orleans back up above sea level.

So far at least, Tamiflu-resistant H5N1 appears limited to part of Vietnam. Tamiflu may be fully effective everywhere else, although this is a sharp warning of what's possible.

Now smooth those feathers a bit more: Tamiflu isn't the only antiviral game in town.

GlaxoSmithKline's drug Relenza also appears effective in reducing avian flu symptoms and death after exposure to the virus. Its seeming weakness proves to be its strength here. While Tamiflu is easily taken either as a pill or an oral suspension, Relenza is inhaled. Because that's bothersome, a lot fewer people have used Relenza, thereby giving H5N1 less chance to develop resistance to it. Indeed, there are no identified cases of Relenza-resistant avian flu.

Yet another drug has, in some animal trials, proved equal to both Tamiflu and Relenza. Called peramivir, in pill form it proved safe in all phases of human clinical trials.