- Article
- Comments ()
- Videos
Pharmacogenomics isn't a word that trips easily off the tongue.
It derives from "pharmacology" and "genomics," which is the study of chromosomes -- all of an organism's inheritable traits. Medical specialists have coined the term to cover an emerging field in biotechnology that is the study of how an individual's genetic makeup affects his or her response to drugs.
While futuristic in sound, and even somewhat in conception, pharmacogenomics contains elements that, in the future, could change the way medicine is practiced, say scientists and educators versed in its practice and potential.
It conceivably has the capacity to deliver very specialized drugs based on a person's genetic profile, according to Alan McKay, dean of the School of Pharmacy at Shenandoah University in Winchester, Va.
Pharmacogenomics is a subset of a broader concept known as personalized medicine, an umbrella term for a range of therapies based on individual need. The development of drugs such as Gleevac, used in certain cases to help alleviate the symptoms of leukemia by interacting with the molecular structure of the disease-causing gene, is part of a movement known as targeted therapy.
Therapy can help alleviate the disease in a patient. Equally important is the need for preventive measures -- diagnostic tests that show who is at risk for a disease -- as well as predictive tests that can tell how an individual patient will react to prescribed medicines and avoid problems associated with the one-size-fits-all approach currently in general use.
The above are the result of the successful completion of the Human Genome Project, which mapped all human genes and set the stage for some remarkable advancements in the biotechnology field. The human genome is made up of an estimated 25,000 to 30,000 individual genes, of which 99.9 percent are identical from one person to another. The remaining one-tenth of 1 percent is what makes each person unique.
"But [it] also creates the variation that leads to genetic diseases, different responses to drugs and challenges for health professionals," Mr. McKay says.
The introduction of a new undergraduate program being offered jointly this fall by Shenandoah and George Washington University underscores his statement that "pharmacogenomics will change everything about the delivery of health care."
The academic major is believed to be the first of its kind in the country to be given at the undergraduate level and is intended to capitalize on the strength of Shenandoah's pharmacy program, combined with GW's emphasis on the basic sciences.









Post a comment
There are comments on this article, submit your opinion!
If you feel there is still something worth mentioning about this entry please contact the author or the site admin.