Digital gamers target disease

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Instead of pitting players against monsters, criminals or aliens, a new computer game enlists them in the real-life fight against other deadly enemies: diseases and viruses.

Gamers who play "Foldit," a computer game developed by University of Washington scientists, will actually be protein folding, a process used to unlock the mysteries of human proteins, which help the body perform countless functions, from breaking down food to carrying oxygen in the blood, but also play roles in some diseases and viruses.

"We're hopefully going to change the way science is done, and who it's done by," said Zoran Popovic, an associate professor of computer science and engineering who was part of the team that developed the game. "Our ultimate goal is to have ordinary people play the game and eventually be candidates for winning the Nobel Prize."

Scientists spend countless hours and dollars trying to better understand the shape and function of proteins, and the creators of "Foldit" hope the game will transform game players into armchair scientists who will help make discoveries about biological mysteries, ranging from Alzheimer's disease to vaccines.

"We're trying to use the brain power of people all around the world to advance biomedical research," said team member David Baker, a professor of biochemistry and a Howard Hughes Medical Institute investigator.

Each protein is made up of an amino acid chain that folds into a particular ideal shape, emitting the lowest amount of energy. The scientific community already knows the genetic makeup of many proteins, but doesn't know how they fold up into these complex shapes.

"Foldit" turns protein folding into a competitive sport, as players click and twist the snakelike 3-D images on their screen. The goal is to condense the protein down to its most compact shape, with the fewest number of gaps or holes. The "Foldit" computer program calculates a score, and high scores are investigated further by the University of Washington scientists.

Finding the ideal structure and shape of a protein "can help you understand what the protein does, how it acts, and might provide a starting point to block its action if it's involved in disease," Mr. Baker said.

Initially, as "Foldit" was tested, about 700 players were given proteins whose ideal structure and shape were already known.

Last week, the game was opened to the public and included proteins with unknown shapes. The University of Washington team presented the game at a gaming conference in Baltimore on Thursday, and now about 30,000 people have played the game, which is available on the Internet at "fold.it"