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CHICAGO (AP) _ Gavin Floyd outpitched Tim Wakefield, and A.J. Pierzynski hit a tiebreaking two-run homer in the seventh.

Chicago’s seventh straight victory over Boston and 14th in the last 16 games between the teams denied the 44-year-old knuckleballing Wakefield his 200th career win.

Floyd (9-9) won his third straight start. He gave up a run and three hits in seven innings, including a homer to Jarrod Saltalamacchia, and ran his career record against the Red Sox to 6-0.

Wakefield (6-4) also allowed three hits in seven innings. But his wild pitch in the sixth helped set up the tying run on Paul Konerko’s sacrifice fly. And he walked Carlos Quentin to start the bottom of the seventh before Pierzynski drove his fifth homer of the season into the right-center field seats to give the White Sox a two-run lead.

Orioles 4, Yankees 2

NEW YORK (AP) _ Jeremy Guthrie shut down the New York Yankees for seven innings, perhaps driving up his price in a trade, and the Baltimore Orioles got homers from Mark Reynolds and Derrek Lee.

Kevin Gregg held on in a shaky ninth, striking out Brett Gardner with runners at the corners to end it.

Reynolds and Lee each drove in two runs, lending some rare offensive support to the major league leader in losses. Guthrie (5-14) allowed just four hits, including Mark Teixeira’s solo homer, and walked three in one of his best outings during a frustrating season.

The right-hander outpitched A.J. Burnett (8-9) for his first win in four career starts at Yankee Stadium. Last-place Baltimore won for the second time in 11 road games, improving to 1-6 against New York this year, as Guthrie moved to 2-7 away from home.