The accident happened a week after another NFL tragedy. Chiefs linebacker Jovan Belcher killed his girlfriend and then committed suicide Dec. 1.
Brent has played in all 12 games this season and has been a bigger presence on defense with starting nose guard Jay Ratliff battling injuries. He made his first career start in the season opener against the New York Giants and has 35 tackles and 1 1/2 sacks.
“On behalf of the entire Colts family, our sincerest condolences go out to Jerry’s family and friends, Colts general manager Ryan Grigson said in a statement. “He was a good teammate that was well liked by all. Today’s tragic news is just another reminder of how fragile life is and how everyday given is a gift.”
Brown played for San Antonio in the Arena Football League this year. In 2011, he played for Jacksonville in the AFL and the Hamilton Tiger-Cats in the Canadian Football League.
He was born and grew up in St. Louis, attending Vashon High School.
Associated Press Writers Michael Graczyk in Houston and Sara Burnett in Chicago contributed to this report.