- Murphy: Israel must be wary of Hamas using civilian deaths for recruitment
- Royce: Putin recruiting ‘every skinhead and malcontent around Russia’
- Nancy Pelosi is adamant: Congress worked together when Bush was president
- ‘Slender Man’ stabbing victim receives Purple Heart from anonymous veteran
- Kentucky city called socialist for buying gas station, undercutting competitor fuel prices
- Israel hits five mosques, sports complex in overnight Gaza strikes
- Hillary Clinton dogged for refusing reporters’ questions on book tour
- EPA tweet baffles: ‘I’m now a C-List celebrity in Kim Kardashian: Hollywood’ iPhone game
- Australian P.M. Abbott: MH17 evidence tampered with on ‘industrial scale’
- Rep. Luis Gutierrez tells Hispanics to vote and ‘punish those’ who oppose amnesty
Miracle diet pill? A safe drug is elusive
Question of the Day
WASHINGTON (AP) — The battle of the bulge has been a big, fat failure for U.S. drugmakers. But that hasn’t stopped them from trying.
For nearly a century, scientists have struggled to make a diet pill that helps people lose weight without side effects that range from embarrassing digestive issues to dangerous heart problems.
Earlier this week, a government panel recommended the FDA approve the latest diet drug Qnexa. The recommendation raises hopes that the U.S. could approve the first anti-obesity drug in more than a decade. It also highlights how challenging it is to create a pill that fights fat in a variety of people without negative side effects. Even Qnexa was previously rejected over concerns that it can cause heart palpitations and birth defects if taken by pregnant women.
“Having a drug for obesity would be like telling me you had a drug for the fever,” said Dr. Mitchell Roslin, chief of bariatric surgery at Northern Westchester Hospital in New York. “There can be millions of different reasons why someone is obese; it’s really a symptom of various underlying mechanisms.”
An effective and safe diet pill would be an easy sale in the U.S.: With more than 75 million obese adults, the nation’s obesity rate is nearing 35 percent. But the biggest problem in creating a weight-loss drug is that there appears to be no safe way to turn off one of the human body’s most fundamental functions.
For millions of years, humans have been programmed to consume calories and store them as energy, or fat. It’s this biological mechanism that makes it almost impossible to quickly lose weight by not eating. Cutting down on food instead sends stronger signals to the body to store more calories.
“Throughout most of human history calories were scarce and hard to get, so we have numerous natural defenses against starvation,” said Dr. David Katz of Yale University’s Prevention Research Center. “We have no defenses against overeating because we never needed them before.”
So, the drug industry has been on a nearly 100-year search for a drug that can help the body shed pounds. It has mostly failed to come up with an effective one and many of the experiments have proven fatal to patients:
— Early attempts focused on speeding up metabolism, or the body’s method for breaking down food into energy. The speed of metabolism controls how quickly or slowly we burn calories and ultimately how much weight we take on
In the 1930s, doctors prescribed an industrial chemical called dinitrophenol, which accelerated metabolism, but also caused fever, swelling and deadly toxicity in some patients. The 1938 law establishing the Food and Drug Administration was a response to untested drugs like dinitrophenol.
— In the ‘50s and ‘60s, amphetamines became popular drugs because they boost metabolism and suppress appetite. But the pills proved to be highly addictive, and doctors discovered they increase blood pressure and heart rate. The amphetamine phentermine is approved for short-term weight loss, usually less than 12 weeks, though it is seldom prescribed because of the potential for addiction.
— Perhaps the worst diet pill safety debacle came in the 1990s and involved the combination of phentermine and another weight loss drug marketed by Wyeth called fenfluramine. The combination of the two pills, dubbed fen-phen, was never approved by the FDA. But because the agency doesn’t regulate doctors’ decisions about prescribing various combinations of drugs, more than 18 million fen-phen prescriptions were written by 1996.
One year later, studies suggested that up to a third of patients taking fen-phen experienced heart valve damage. In 1997, Wyeth was forced to recall two versions of fenfluramine and eventually paid more than $13 billion to settle tens of thousands of personal injury lawsuits.
— In the last decade, drugmakers have moved toward other weight loss concoctions. Currently, the only drug approved for long-term weight loss in the U.S. is orlistat, which is sold as the prescription drug Xenical and over the counter as alli. The drug works by blocking the absorption of fat.
When launched in 2007, alli received a high-profile marketing push from drugmaker GlaxoSmithKline, complete with TV ads and a celebrity endorsement by country singer Wynonna Judd. But it never took off due to unpleasant side effects, including loose bowel movements. Educational pamphlets for alli even recommend people start the program when they have a few days off work, or bring an extra pair of pants to the office.
TWT Video Picks
U.S. appetite for drugs begets violence migrants are fleeing
- IRS seeks help destroying another 3,200 computer hard drives
- Jewish woman booted from JetBlue flight over fight with Palestinian
- Hillary Clinton dogged for refusing reporters' questions on book tour
- YOUNG: A sinking presidency, deeper after November?
- PRUDEN: A deadly enemy within exacerbating immigration crisis
- Rep. Jared Polis' anti-fracking crusade riles Colorado
- MERRY: Handicaps in Hillary's way
- Hamas terrorists wear Israeli army uniforms to ambush soldiers in Gaza
- U.S. scrambles as violence escalates in Israel-Hamas conflict
- Edward Snowden to work with Russia on anti-spy technology
Obama's biggest White House 'fails'
Celebrities turned politicians
Athletes turned actors
20 gadgets that changed the world
Fighting in Iraq