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The two have combined for 1,410 yards from scrimmage _ nearly half of Buffalo’s 3,228 yards offense _ and accounted for nine of 24 touchdowns scored on offense. Buffalo ranks sixth in the NFL in yards rushing and second in averaging 5.3 yards per carry.

Jackson has already missed two games after spraining his right knee in a season-opening 48-28 loss to the New York Jets. Spiller also capably filled in last year in a full-time role after Jackson missed the final six games with a broken bone in his right leg.

“As an offense, we’re definitely going to miss him because he brings so much to our team,” said Spiller, who leads NFL running backs in average 7.3 yards a carry. “But this is familiar territory for me.”

The Bills have been careful to limit Spiller’s carries even when Jackson’s been out. His career high came last year, when he had 19 carries in a 28-24 loss to the New York Jets.

“I’m not worried about how many times I touch it. I’m just pretty much, from here on out, just worried about wins,” Spiller said. “I’m just trying to help my team win so we can experience what it feels like to play in the playoffs.”

That’s a long-shot at best for a Bills team that’s lost five of six and finds itself in jeopardy of extending its postseason drought to 13 seasons.

Gailey remains upbeat about the Bills chances to make a run, and is encouraged after seeing signs of the team playing better in its past two games, including a 21-9 loss at Houston two weeks ago.

“We did not win, but we played fairly well against two of the best teams in the AFC,” Gailey said. “And I think if we will continue to get better that will help us with the future and the rest of our schedule.”

NOTES: The Bills announced the game Thursday is a sellout. The team said at least 10,000 tickets are available for each of its final three games at Ralph Wilson Stadium this season. … The Bills signed DB Delano Howell to their practice squad three days after he was released from the team’s active roster. … The Bills 35 first downs against New England set a team record.

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