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No. 4 Agnieszka Radwanska, 2011 French Open champion Li Na, No. 5 Angelique Kerber and 17-year-old American wild card Madison Keys all advanced in straight sets.

Novak Djokovic also advanced to the third round, extending his winning streak at Melbourne Park to 16 with a 6-1, 6-2, 6-3 win over 20-year-old American Ryan Harrison.

He’s on track for a record third consecutive Australian Open title and doesn’t have any other major winners on his half of the draw after Rafael Nadal withdrew and Federer, Andy Murray and Juan Martin del Potro landed on the opposite side.

Fourth-ranked David Ferrer beat American Tim Smyczek 6-0, 7-5, 4-6, 6-3. No. 5 Tomas Berdych defeated Guillaume Rufin of France 6-2, 6-2, 6-4, and No. 8 Janko Tipsarevic took almost four hours to oust Lukas Lacko 6-3, 6-4, 3-6, 4-6, 7-5.

No. 20 Sam Querrey moved on when fellow American Brian Baker retired in the second set with an injured right knee and was pushed off Court 6 in a wheelchair.

“He’s the last person that deserves anything like that with his five or six surgeries already,” Querrey said.