- The Washington Times - Wednesday, October 26, 2005

NEW YORK (AP) — Scientists have mapped patterns of tiny differences in DNA that distinguish one person from another, an achievement that will help researchers find genes that promote common illnesses such as heart disease and diabetes.

The map represents “a real sea change in how we study the genetics of disease,” said Dr. David Altshuler, a leader of the project, which included more than 200 researchers from six nations.

Scientists want to find disease-related genes as a means for diagnosis, prediction and treatment. Such genes give clues to the biological underpinnings of disease, and so suggest strategies for developing therapies.

Genes that predispose people to common disorders — heart disease, cancer, diabetes, asthma and others — are devilishly hard to find.

But the new “HapMap,” taken from the genetics term haplotype, opens the door to starting comprehensive searches through the human DNA for those genes, said Dr. Altshuler, who conducts research at the Broad Institute, which is a collaboration of Harvard University and the Massachusetts Institute of Technology, and at Massachusetts General Hospital.

It is not clear how many genes will be found or how useful they will be, Dr. Altshuler said. The achievement probably won’t result in disease treatments for five or 10 years or more, he said.

HapMap data already have been used to track down a gene linked to the eye disorder macular degeneration, said HapMap project participant Dr. Lincoln Stein of the Cold Spring Harbor Laboratory in New York state.

The map is described in today’s issue of the journal Nature. Participating scientists came from Canada, China, Japan, Nigeria, the United Kingdom and the United States. The project analyzed DNA samples from 269 persons from Nigeria, Beijing, Tokyo and Utah.

“It is a triumph for collaborative science,” said Health and Human Services Secretary Michael O. Leavitt. “This is a landmark achievement.”

Human DNA consists of more than 3 billion building blocks whose sequences form genes, just like letters spell a word. For any two unrelated persons, these letters are 99.9 percent the same. But that leaves millions of single-letter differences, called SNPs (pronounced “snips”) that provide genetic variation among people.

The HapMap shows how more than 1 million of these SNPs form patterns: A person with one particular version of a SNP is likely to carry particular versions of other SNPs as well. A group of variants that associate together is called a haplotype.

This clustering greatly simplifies the task of analyzing what variations a person carries, because not all of them have to be identified.

This, in turn, allows scientists to use great arrays of SNPs as signposts for tracing genes that promote disease or determine a person’s response to a particular medicine.

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