- The Washington Times - Friday, November 3, 2017

A new medication meant for the treatment of breast cancer and diabetes is found to have the side effect of clearing potentially fatal fat that blocks arteries, researchers at the University of Aberdeen announced on Thursday, following pre-clinical mice testing.

The researchers gave mice just a single does of the experimental drug, Trodisquemine, and found it “completely reversed the effects of a disease that causes a host of heart problems,” a statement from the university read.

The dose of medication was found to decrease the amount of fatty plaque in their arteries, a condition called atherosclerosis, the main cause between heart attacks and strokes.

“These have only been tested at pre-clinical level, in mice, so far but the results were quite impressive and showed that just a single dose of this drug seemed to completely reverse the effects of atherosclerosis,” lead researchers of the study, Mirela Delibegovic and Dr. Dawn Thompson, said in the statement.

“The next step is to test the ability of this drug to improve outcomes in human patients with developed atherosclerosis and cardiovascular disease,” they said.



The drug functions to stop an enzyme called PTP1B, with high levels present in people with obesity or diabetic conditions and chronic inflammation, the statement continued. In addition, the drug blocked the protein AMPK, “which effectively mimics exercise and reduces chronic inflammation,” reducing the fatty buildup.

“Trodusquemine is in early clinical trials for the treatment of diabetes. This study shows it can also limit the build-up of fatty atherosclerotic plaques in mice. If we see the same effect in patients, the drug may prove even more useful than currently hoped for,” said Jeremy Pearson, associate medical director at the British Heart Foundation, which funded the study.

Sign up for Daily Newsletters

Manage Newsletters

Copyright © 2021 The Washington Times, LLC. Click here for reprint permission.

Please read our comment policy before commenting.

 

Click to Read More and View Comments

Click to Hide