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Sen. Frank Lautenberg, New Jersey Democrat, said it was “beyond belief” that, in the wake of the Newtown tragedy, the gun organization’s leaders “want to fill our communities with guns and arm more Americans.”

“The NRA points the finger of blame everywhere and anywhere it can, but they cannot escape the devastating effects of their reckless comments and irresponsible lobbying tactics,” said Mr. Lautenberg, who has introduced legislation to ban magazines that hold more than 10 rounds of ammunition. “The NRA leadership is wildly out of touch with its own members, responsible gun owners, and the American public who want to close dangerous loopholes and enact common-sense gun safety reform. It is clear that their real priority is to help gun manufacturers sell more guns — not to protect our children or Americans’ rights. The extreme rhetoric of Wayne LaPierre and the NRA is disturbing and dangerous, and will only exacerbate America’s deadly culture of gun violence.”

U.S. House Minority Whip Steny Hoyer, Maryland Democrat, appeared to agree with that sentiment, saying he would be surprised if even a majority of NRA members agree with Mr. LaPierre’s remarks.

“I do not believe those remarks represent anywhere near a significant portion of America,” Mr. Hoyer said. “I am very hopeful that we will go in a direction that will say these weapons of mass killing capability will be limited.”

New York City Mayor Michael R. Bloomberg, a staunch gun-control advocate, lambasted the group and called the press conference “a shameful evasion of the crisis facing our country.”

“Instead of offering solutions to a problem they have helped create, they offered a paranoid, dystopian vision of a more dangerous and violent America where everyone is armed, and no place is safe,” Mr. Bloomberg said. “Leadership is about taking responsibility, especially in times of crisis. Today the NRA’s lobbyists blamed everyone but themselves for the crisis of gun violence.”

Two protesters — one holding up a pink sign reading, “NRA killing our children” — interrupted Mr. LaPierre during his remarks at the Willard Hotel in downtown D.C., and they were escorted out of the room.

NRA President David Keene said at the outset of the briefing that the group would take no questions from the press on its statement until next week, and Mr. LaPierre ignored questions shouted at him as he walked off the stage.

While the debate on gun control, mental health and a “culture of violence” in the country raged for days on Capitol Hill, the country’s most powerful gun-rights lobbying group had remained largely silent.

“Out of respect for the families and until the facts are known, the NRA has refrained from comment,” Mr. LaPierre said Friday.

On Tuesday, the group released a statement saying the group was “saddened” and “heartbroken” by news of the event, saying it was “prepared to offer meaningful contributions to make sure this never happens again.”

Mr. LaPierre’s Friday remarks came on the same day the White House and many government entities around the country held a moment of silence at 9:30 a.m. for the victims of last week’s shootings.

In the last week, an online petition calling for Congress to immediately act on the issue of gun control posted on the White House’s “We the People” section has garnered 400,000 signatures, making it one of the most popular petitions during Mr. Obama’s first term.

In a video response to the petition, President Obama called on Americans across the country who are fed up with the outbreaks of violence to keep the pressure on Congress to act.

Earlier this week, Mr. Obama said he supports reinstating a ban on assault weapons and large magazine clips as part of a broader look at mental-health issues and violent influences on youths.

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