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The United Nations says some 70,000 people have been killed since the uprising against Mr. Assad’s authoritarian rule began in March 2011. The violence has spread humanitarian suffering across much of Syria.

U.N. humanitarian chief Valerie Amos said the number of people in need of humanitarian assistance has quadrupled since June last year.

“Just in the last two months, over 250,000 people have fled into neighboring countries. These numbers, they are not sustainable,” she said at a press conference in Geneva.

The United Nations says more than 870,000 Syrians have fled to neighboring countries since the beginning of the conflict, with the majority seeking refuge in Jordan, Turkey and Lebanon.

The United States announced Tuesday it was providing an addition $19 million in humanitarian assistance in response to urgent needs in Syria.

The announcement made in Geneva by Nancy Lindborg, assistant administrator for the U.S. Agency for International Development, brings the total U.S. contribution of humanitarian support in response to this crisis to nearly $385 million.

On Jan. 29, President Obama announced an additional $155 million to help those suffering inside Syria and refugees in the neighboring countries.

The United Nations warned in a report released Monday that contaminated water and poor hygiene in populated areas have led to an increase in waterborne diseases such as hepatitis A and typhoid.

The World Health Organization said the health situation on the ground is rapidly deteriorating, with an estimated 2,500 people in the northeastern Deir el-Zour province infected with typhoid and 14,000 cases of leishmaniasis, an infectious and often debilitating disease caused by parasites, in Hassakeh province.

• Associated Press writers Albert Aji in Damascus, Bassem Mroue and Ben Hubbard in Beirut, Frank Jordan in Berlin and Nataliya Vasilyeva in Moscow contributed to this article.