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“We have undertaken the most aggressive oil and gas safety and reform agenda in U.S. history, raising the bar on offshore drilling safety, practices and technology,” he said.

Mr. Salazar and Ms. Jackson may not be the last members of the president’s energy and environment team to head for the exit. There has been widespread speculation that Energy Secretary Steven Chu will announce his resignation soon.

In what could be an indication of his departure, one of his top advisers, Richard Kauffman, recently left his post at the Energy Department to serve as New York’s energy czar.